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OCR: s rapidly Replacement therapy with glucocortico osterone suppresses ACTH levels and hence cor Its in and deoxycorticosterone levels. This re blyte correction of the hypertension and elec abnormalities. In the presence of 11ß-hydroxylase defi ndary defective cortisol secretion leads to a se a. elevation of ACTH and to bilateral adre rculating hyperplasia. In addition, there are high osterone levels of 11-deoxycortisol and deoxycor rilism as a present. Hypertension ensues, as does he process result of the elevated androgen levels. ment can be reversed by glucocorticoid repla therapy.